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- Erstellungsdatum 6. Juli 2023
- Zuletzt aktualisiert 6. Juli 2023
The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inﬂammation and Angiogenesis
Abstract: Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for surgery is a potential new treatment
application, which may reduce complication rates and hospital stay. In this review, the effect of HBOT on oxidative stress, inﬂammation and angiogenesis is investigated to better understand the potential mechanisms underlying preconditioning for surgery using HBOT. A systematic search was conducted to retrieve studies measuring markers of oxidative stress, inﬂammation, or angiogenesis in humans. Analysis of the included studies showed that HBOT-induced oxidative stress reduces the concentrations of pro-inﬂammatory acute phase proteins, interleukins and cytokines and increases growth factors and other pro-angiogenesis cytokines. Several articles only noted this surge after the ﬁrst HBOT session or for a short duration after each session. The anti-inﬂammatory status following HBOT may be mediated by hyperoxia interfering with NF-κB and IκBα. Further research into the effect of HBOT on inﬂammation and angiogenesis is needed to determine the implications of these ﬁndings for clinical practice.